Article
Inhibition of Smooth Muscle β-Catenin Hinders Neointima Formation After Vascular Injury.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2017
Riascos-Bernal Dario F, Chinnasamy Prameladevi, Gross Jordana N, Almonte Vanessa, Egaña-Gorroño Lander, Parikh Dippal, Jayakumar Smitha, Guo Liang, Sibinga Nicholas E S
Abstract excerpt
OBJECTIVE: Smooth muscle cells (SMCs) contribute to neointima formation after vascular injury. Although β-catenin expression is induced after injury, whether its function is essential in SMCs for neointimal growth is unknown. Moreover, although inhibitors of β-catenin have been developed, their effects on SMC growth have not been tested. We assessed the requirement for SMC β-catenin in short-term vascular...
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