Article
Myocardin/microRNA-30a/Beclin1 signaling controls the phenotypic modulation of vascular smooth muscle cells by regulating autophagy.
Cell death & disease - 8 Feb 2022
Shi Danyang, Ding Jinhua, Xie Shouqiang, Huang Lei, Zhang Hongmin, Chen Xiaojie, Ren Xuejun, Zhou Sa, He Hongpeng, Ma Wenjian, Zhang Tongcun, Wang Nan
Abstract excerpt
Upon vascular injury, vascular smooth muscle cells (VSMCs) change from a contractile phenotype to a synthetic phenotype, thereby leading to atherogenesis and arterial restenosis. Myocardin (MYOCD) is essential for maintaining the contractile phenotype of VSMCs. Deletion of MYOCD in VSMCs triggers autophagy. However, the molecular mechanism underlying the effect of MYOCD on autophagy is not clear. In this study,...
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