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Article

Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons.

Developmental cell - 1 Feb 2008

Pauli Andrea, Althoff Friederike, Oliveira Raquel A, Heidmann Stefan, Schuldiner Oren, Lehner Christian F, Dickson Barry J, Nasmyth Kim

Abstract excerpt

Cohesin is a highly conserved multisubunit complex that holds sister chromatids together in mitotic cells. At the metaphase to anaphase transition, proteolytic cleavage of the alpha kleisin subunit (Rad21) by separase causes cohesin's dissociation from chromosomes and triggers sister-chromatid disjunction. To investigate cohesin's function in postmitotic cells, where it is widely expressed, we have created fruit...

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Identifiers

PMID: 18267092
DOI: 10.1016/j.devcel.2007.12.009
PMCID: PMC2258333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons.PMID 18267092Read ↗

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