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Rapid proteolysis of RAD21 in primary cells defines the role of cohesin in cell type-specific gene expression

2020-01-01

Abstract excerpt

Cohesin contributes to the organisation of the mammalian genome in 3D space, but its role in gene regulation remains poorly understood. To address this role, I have implemented a system that enables temporal control over cohesin function in primary mammalian cells by the inducible cleavage of the essential cohesin subunit RAD21, using tobacco etch virus protease (RAD21-TEV). Building on previous work in the lab th...

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Literature Corpus work
c96798f6-2eae-5c1e-8339-6972da4e54b3
DOI
10.25560/89084
Open publication

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Rapid proteolysis of RAD21 in primary cells defines the role of cohesin in cell type-specific gene expressionDOI 10.25560/89084
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