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Article

NFκB-dependent Control of BACE1 Promoter Transactivation by Aβ42

9 Feb 2008

Abstract excerpt

Beta-amyloid (Abeta) peptides that accumulate in Alzheimer disease are generated from the beta-amyloid precursor protein (betaAPP) by cleavages by beta-secretase BACE1 and by presenilin-dependent gamma-secretase activities. Very few data document a putative cross-talk between these proteases and the regulatory mechanisms underlying such interaction. We show that presenilin deficiency lowers BACE1 maturation and...

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PMID: 18263584
DOI: 10.1074/jbc.m706579200

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