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Article

Two nuclear factor binding domains activate expression from the human amyloid beta-protein precursor promoter.

The Journal of biological chemistry - 19 Aug 1994

Quitschke W W

Abstract excerpt

Amyloid beta-protein is derived from the amyloid beta-protein precursor (APP), and it is a major component of brain amyloid depositions in Alzheimer's disease and Down's syndrome. Overexpression of APP may be one of several factors contributing to amyloid formation. The APP promoter was therefore analyzed to determine the mechanism by which APP gene expression is regulated. Cell type-specific expression from the...

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Source

Identifiers

PMID: 8063744

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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