Two nuclear factor binding domains activate expression from the human amyloid beta-protein precursor promoter.

Article

Two nuclear factor binding domains activate expression from the human amyloid beta-protein precursor promoter.

The Journal of biological chemistry - 19 Aug 1994

Quitschke W W

Abstract excerpt

Amyloid beta-protein is derived from the amyloid beta-protein precursor (APP), and it is a major component of brain amyloid depositions in Alzheimer's disease and Down's syndrome. Overexpression of APP may be one of several factors contributing to amyloid formation. The APP promoter was therefore...

Topics

Amyloid beta-Protein Precursor
Animals
Base Sequence
Binding Sites
DNA
Gene Expression Regulation
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Nuclear Proteins
PC12 Cells
Promoter Regions, Genetic

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