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Article

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

The Journal of biological chemistry - 4 Jun 2004

Cao Xinwei, Südhof Thomas C

Abstract excerpt

Amyloid-beta precursor protein (APP) forms a transcriptionally active complex with the adaptor protein Fe65 and the histone acetyltransferase Tip60, but the mechanism of transcriptional activation that is mediated by APP and Fe65 remains unclear. APP is cleaved by gamma-secretase similar to Notch...

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Source

Identifiers

PMID: 15044485
DOI: 10.1074/jbc.M402248200

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15044485-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.PMID 15044485Read ↗

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