Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

27 Apr 2005

Abstract excerpt

Amyloid beta protein (Abeta) is the principal component of neuritic plaques in Alzheimer's disease (AD). Abeta is derived from beta amyloid precursor protein (APP) by beta- and gamma-secretases. Beta-site APP cleaving enzyme 1 (BACE1) has been identified as the major beta-secretase. BACE2 is the homolog of BACE1. The BACE2 gene is on chromosome 21 and has been implicated in the pathogenesis of AD. However, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Bioinformatics and Genomic Networks
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15857888
DOI: 10.1096/fj.04-3426com

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genesPMID 15857888Read ↗

Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1Semantic proximity Read ↗

Association studies using novel polymorphisms in BACE1 and BACE2.Semantic proximity Read ↗

Gene structure and organization of the human β‐secretase ( <i>BACE</i> ) promoterSemantic proximity Read ↗

BACE2: A Promising Neuroprotective Candidate for Alzheimer’s DiseaseSemantic proximity Read ↗

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2Semantic proximity Read ↗

Regulation of β‐site APP‐cleaving enzyme 1 gene expression and its role in Alzheimer’s DiseaseSemantic proximity Read ↗

The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology.Semantic proximity Read ↗

BACE2, as a novel APP θ‐secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndromeSemantic proximity Read ↗

Splice variants of the Alzheimer's disease beta-secretase, BACE1.Semantic proximity Read ↗

BACE1 Structure and Function in Health and Alzheimers DiseaseSemantic proximity Read ↗

Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer’s Disease and CSF Amyloid Biomarkers in APOE ε4 Non-CarriersSemantic proximity Read ↗

Cloning and expression of the rat BACE1 promoterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.