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Article

Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly.

Journal of lipid research - 1 May 2010

Polisecki Eliana, Peter Inga, Simon Jason S, Hegele Robert A, Robertson Michele, Ford Ian, Shepherd James, Packard Christopher, Jukema J Wouter, de Craen Anton J M, Westendorp Rudi G J, Buckley Brendan M, Schaefer Ernst J

Abstract excerpt

Niemann-Pick C1-like 1 protein (NPC1L1) plays a critical role in intestinal cholesterol absorption. Our objective was to examine whether five variants (-133A>G, -18A>C, L272L, V1296V, and U3_28650A>G) at the NPC1L1 gene have effects on lipid levels, prevalence, and incidence of coronary heart disease (CHD) and lipid-lowering response to pravastatin. We studied 5,804 elderly participants from the PROSPER study,...

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Identifiers

PMID: 19752398
DOI: 10.1194/jlr.P001172
PMCID: PMC2853447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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