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Article

Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses.

BMC medical genetics - 6 Oct 2011

Trompet Stella, de Craen Anton J M, Postmus Iris, Ford Ian, Sattar Naveed, Caslake Muriel, Stott David J, Buckley Brendan M, Sacks Frank, Devlin James J, Slagboom P Eline, Westendorp Rudi G J, Jukema J Wouter

Abstract excerpt

BACKGROUND: The PHArmacogenetic study of Statins in the Elderly at risk (PHASE) is a genome wide association study in the PROspective Study of Pravastatin in the Elderly at risk for vascular disease (PROSPER) that investigates the genetic variation responsible for the individual variation in drug response to pravastatin. Statins lower LDL-cholesterol in general by 30%, however not in all subjects. Moreover,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21977987
DOI: 10.1186/1471-2350-12-131
PMCID: PMC3207930

Genes

APOC1
APOE
LDLR
FADS2
FEN1
HMGCR
PSRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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