Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly.

doi:10.1016/j.atherosclerosis.2011.09.028

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Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly.

Atherosclerosis - 1 Feb 2012

Akao Hironobu, Polisecki Eliana, Kajinami Kouji, Trompet Stella, Robertson Michele, Ford Ian, Jukema J Wouter, de Craen Anton J M, Westendorp Rudi G J, Shepherd James, Packard Christopher, Buckley Brendan M, Schaefer Ernst J

Abstract excerpt

Our goal was to determine whether genetic variation at genes affecting statin metabolism or targets of statin therapy would influence low density lipoprotein (LDL) cholesterol lowering with pravastatin, baseline heart disease, or cardiac endpoints on trial. We examined associations of single nucleotide polymorphisms (SNPs) at the liver X receptor alpha (LXRA, rs12221497), and the solute carrier organic anion...

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PMID: 22189199
DOI: 10.1016/j.atherosclerosis.2011.09.028

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