ABCA1 gene variation and heart disease risk reduction in the elderly during pravastatin treatment.

doi:10.1016/j.atherosclerosis.2014.04.030

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Article

ABCA1 gene variation and heart disease risk reduction in the elderly during pravastatin treatment.

Atherosclerosis - 1 Jul 2014

Akao Hironobu, Polisecki Eliana, Schaefer Ernst J, Trompet Stella, Robertson Michele, Ford Ian, Jukema J Wouter, de Craen Anton J M, Packard Christopher, Buckley Brendan M, Kajinami Kouji

Abstract excerpt

AIMS: Our goals were to examine the relationships of a specific ATP-binding cassette transporter A1 (ABCA1) variant, rs2230806 (R219K), on baseline lipids, low-density lipoprotein cholesterol (LDL-C) lowering due to pravastatin, baseline heart disease, and cardiac endpoints on trial. METHODS AND RESULTS: The ABCA1 R219K variant was assessed in 5414 participants in PROSPER (PROspective Study of Pravastatin in the...

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Identifiers

PMID: 24854628
DOI: 10.1016/j.atherosclerosis.2014.04.030
PMCID: PMC4556353

Genes

ABCA1

Variants

rs2230806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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