Article
Mutation spectrum of copper-induced DNA damage.
The Journal of biological chemistry - 5 Apr 1991
Tkeshelashvili L K, McBride T, Spence K, Loeb L A
Abstract excerpt
The ability of metal ions to damage DNA and cause mutagenesis has been analyzed with reversion and forward mutation assays using single-stranded DNA templates. We previously reported that incubation of phi X174 am3 DNA with Fe2+ in vitro results in mutagenesis when the treated DNA is transfected...
Topics
- Bacteriophage phi X 174
- Base Sequence
- Copper
- DNA Damage
- DNA, Bacterial
- DNA, Viral
- Escherichia coli
- Genes, Bacterial
- Genes, Viral
- Molecular Sequence Data
- Mutagenicity Tests
- Mutation
- Transfection