Article
Mutation spectrum of copper-induced DNA damage.
The Journal of biological chemistry - 5 Apr 1991
Tkeshelashvili L K, McBride T, Spence K, Loeb L A
Abstract excerpt
The ability of metal ions to damage DNA and cause mutagenesis has been analyzed with reversion and forward mutation assays using single-stranded DNA templates. We previously reported that incubation of phi X174 am3 DNA with Fe2+ in vitro results in mutagenesis when the treated DNA is transfected into Escherichia coli spheroplasts (Loeb, L. A., James, E. A., Waltersdorph, A. M., and Klebanoff, S. J. (1988) Proc....
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