Article
Mutational biases associated with potential iron-binding DNA motifs in rodent lacI and human p53 mutational databases.
Mutation research - 4 Jun 2004
Sonntag David M, de Boer Johan, Medvedovic Mario, Baxter C Stuart, LeMasters Grace, Talaska Glenn
Abstract excerpt
The role of Fenton oxidants in DNA damage, aging, and cancer is appreciated, but not well understood. Six potential iron-binding (PIB) DNA motifs were previously identified as sites of preferential strand cleavage. Since DNA-metal binding domains are a known determinant of oxidative DNA damage, and the location of strand breaks explains where oxidant attack occurs, we sought to determine whether the likelihood of...
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