Article
Nickel induces a signature mutation for oxygen free radical damage.
Cancer research - 15 Sept 1993
Tkeshelashvili L K, Reid T M, McBride T J, Loeb L A
Abstract excerpt
We have determined the specificity of mutations produced by nickel(II), a known human carcinogen, in a forward mutation assay and also used a sensitive reversion assay to show that Ni(II), like iron and copper, can produce tandem double CC-->TT mutations, a hallmark of damage to DNA by either UV irradiation or oxygen free radicals. A reduction in mutation frequencies by the addition of oxygen radical scavengers...
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