Article
Combinations of chlorocatechols and heavy metals cause DNA degradation in vitro but must not result in increased mutation rates in vivo.
Environmental and molecular mutagenesis - 1 Jan 1999
Schweigert N, Belkin S, Leong-Morgenthaler P, Zehnder A J, Eggen R I
Abstract excerpt
Chlorocatechols introduced into the environment directly or as a result of degradation processes are highly toxic, particularly when combined with heavy metals. With in vitro DNA degradation assays, the high reactivity of chlorocatechols combined with heavy metals could be shown, whereby copper was shown to be more active than iron. Structure-activity analysis showed that the degradation potential of the...
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