Article
Induction of apoptosis by Drosophila Myc.
Genesis (New York, N.Y. : 2000) - 1 Feb 2008
Montero Lilian, Müller Nadine, Gallant Peter
Abstract excerpt
Myc proteins are essential regulators of cellular growth and proliferation during normal development. Activating mutations in myc genes result in excessive growth and are frequently associated with human cancers. At the same time, forced expression of Myc sensitizes vertebrate cells towards different pro-apoptotic stimuli. Recently, the ability of overexpressed Myc to induce cell-autonomous apoptosis has been...
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