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Article

c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL.

Molecular and cellular biology - 1 Oct 2003

Maclean Kirsteen H, Keller Ulrich B, Rodriguez-Galindo Carlos, Nilsson Jonas A, Cleveland John L

Abstract excerpt

Alterations in MYC and p53 are hallmarks of cancer. p53 coordinates the response to gamma irradiation (gamma-IR) by either triggering apoptosis or cell cycle arrest. c-Myc activates the p53 apoptotic checkpoint, and thus tumors overexpressing MYC often harbor p53 mutations. Nonetheless, many of these cancers are responsive to therapy, suggesting that Myc may sensitize cells to gamma-IR independent of p53. In...

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Identifiers

PMID: 14517295
DOI: 10.1128/MCB.23.20.7256-7270.2003
PMCID: PMC230315

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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