Article
The conserved Myc box 2 and Myc box 3 regions are important, but not essential, for Myc function in vivo.
Gene - 1 May 2009
Schwinkendorf D, Gallant P
Abstract excerpt
Myc proto-oncoproteins are important regulators of growth and proliferation in development. Their functions have been evolutionarily conserved from insects to vertebrates, although the sequence conservation is limited to a few short domains. Here, we analyze the requirement for the most highly conserved domains, called Myc boxes 2 and 3 (MB2 and MB3), and for the weakly conserved N-terminus for the biological...
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