Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis.

Article

Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis.

Oncogene - 6 Jul 1995

Hsu B, Marin M C, el-Naggar A K, Stephens L C, Brisbay S, McDonnell T J

Abstract excerpt

Deregulation of c-myc, frequently implicated in oncogenesis, is associated with increased cell proliferation and also cell death. Similarly, the p53 tumor suppressor gene commonly mutated in human tumors, is known to induce apoptosis or cell cycle arrest in its wild-type conformation. Genetically...

Topics

Alleles
Animals
Apoptosis
Base Sequence
Cell Division
Chromosome Deletion
DNA Primers
Genes, myc
Genes, p53
Heterozygote
Lymphoma
Mice
Mice, Transgenic
Molecular Sequence Data

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