Article
Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis.
Oncogene - 6 Jul 1995
Hsu B, Marin M C, el-Naggar A K, Stephens L C, Brisbay S, McDonnell T J
Abstract excerpt
Deregulation of c-myc, frequently implicated in oncogenesis, is associated with increased cell proliferation and also cell death. Similarly, the p53 tumor suppressor gene commonly mutated in human tumors, is known to induce apoptosis or cell cycle arrest in its wild-type conformation. Genetically altered mice simultaneously overexpressing c-myc and possessing a disrupted p53 gene were used to investigate whether...
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