Article
Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster.
Molecular and cellular biology - 1 Nov 2005
Benassayag C, Montero L, Colombié N, Gallant P, Cribbs D, Morello D
Abstract excerpt
The human c-myc proto-oncogene, implicated in the control of many cellular processes including cell growth and apoptosis, encodes three isoforms which differ in their N-terminal region. The functions of these isoforms have never been addressed in vivo. Here, we used Drosophila melanogaster to examine their functions in a fully integrated system. First, we established that the human c-Myc protein can rescue lethal...
Topics
- Alleles
- Amino Acid Motifs
- Animals
- Apoptosis
- Cell Cycle
- Cell Proliferation
- Cloning, Molecular
- Drosophila melanogaster
- Exons
- Female
- Flow Cytometry