Article
Myc-dependent genome instability and lifespan in Drosophila.
PloS one - 1 Jan 2013
Greer Christina, Lee Moonsook, Westerhof Maaike, Milholland Brandon, Spokony Rebecca, Vijg Jan, Secombe Julie
Abstract excerpt
The Myc family of transcription factors are key regulators of cell growth and proliferation that are dysregulated in a large number of human cancers. When overexpressed, Myc family proteins also cause genomic instability, a hallmark of both transformed and aging cells. Using an in vivo lacZ mutation reporter, we show that overexpression of Myc in Drosophila increases the frequency of large genome rearrangements...
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