Article
Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster.
G3 (Bethesda, Md.) - 4 Sept 2024
Szlanka Tamás, Lukacsovich Tamás, Bálint Éva, Virágh Erika, Szabó Kornélia, Hajdu Ildikó, Molnár Enikő, Lin Yu-Hsien, Zvara Ágnes, Kelemen-Valkony Ildikó, Méhi Orsolya, Török István, Hegedűs Zoltán, Kiss Brigitta, Ramasz Beáta, Magdalena Laura M, Puskás László, Mechler Bernard M, Fónagy Adrien, Asztalos Zoltán, Steinbach Gábor, Žurovec Michal, Boros Imre, Kiss István
Abstract excerpt
One of the major functions of programmed cell death (apoptosis) is the removal of cells that suffered oncogenic mutations, thereby preventing cancerous transformation. By making use of a Double-Headed-EP (DEP) transposon, a P element derivative made in our laboratory, we made an insertional mutagenesis screen in Drosophila melanogaster to identify genes that, when overexpressed, suppress the p53-activated...
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