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Article

Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress

19 Dec 2018

Abstract excerpt

The tumor suppressor TP53/p53 is a known regulator of apoptosis and macroautophagy/autophagy. However, the molecular mechanism by which TP53 regulates 2 apparently incompatible processes remains unknown. We found that Drosophila lacking p53 displayed impaired autophagic flux, higher caspase activation and mortality in response to oxidative stress compared with wild-type flies. Moreover, autophagy and apoptosis...

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PMID: 30563404
DOI: 10.1080/15548627.2018.1558001

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