Article
Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing.
Journal of virology - 1 Apr 2008
Salazar-Gonzalez Jesus F, Bailes Elizabeth, Pham Kimmy T, Salazar Maria G, Guffey M Brad, Keele Brandon F, Derdeyn Cynthia A, Farmer Paul, Hunter Eric, Allen Susan, Manigart Olivier, Mulenga Joseph, Anderson Jeffrey A, Swanstrom Ronald, Haynes Barton F, Athreya Gayathri S, Korber Bette T M, Sharp Paul M, Shaw George M, Hahn Beatrice H
Abstract excerpt
Accurate identification of the transmitted virus and sequences evolving from it could be instrumental in elucidating the transmission of human immunodeficiency virus type 1 (HIV-1) and in developing vaccines, drugs, or microbicides to prevent infection. Here we describe an experimental approach to analyze HIV-1 env genes as intact genetic units amplified from plasma virion RNA by single-genome amplification...
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