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Article

Modeling sequence evolution in acute HIV-1 infection.

Journal of theoretical biology - 21 Nov 2009

Lee Ha Youn, Giorgi Elena E, Keele Brandon F, Gaschen Brian, Athreya Gayathri S, Salazar-Gonzalez Jesus F, Pham Kimmy T, Goepfert Paul A, Kilby J Michael, Saag Michael S, Delwart Eric L, Busch Michael P, Hahn Beatrice H, Shaw George M, Korber Bette T, Bhattacharya Tanmoy, Perelson Alan S

Abstract excerpt

We describe a mathematical model and Monte Carlo (MC) simulation of viral evolution during acute infection. We consider both synchronous and asynchronous processes of viral infection of new target cells. The model enables an assessment of the expected sequence diversity in new HIV-1 infections or...

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Source

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Identifiers

PMID: 19660475
DOI: 10.1016/j.jtbi.2009.07.038
PMCID: PMC2760689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19660475-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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