Article
Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.
The Journal of biological chemistry - 4 Apr 2008
Hocking Henry G, Herbert Andrew P, Kavanagh David, Soares Dinesh C, Ferreira Viviana P, Pangburn Michael K, Uhrín Dusan, Barlow Paul N
Abstract excerpt
Factor H is a regulatory glycoprotein of the complement system. We expressed the three N-terminal complement control protein modules of human factor H (FH1-3) and confirmed FH1-3 to be the minimal unit with cofactor activity for C3b proteolysis by factor I. We reconstructed FH1-3 from NMR-derived structures of FH1-2 and FH2-3 revealing an approximately 105-A-long rod-like arrangement of the modules. In structural...
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