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Article

Structural basis for complement factor H linked age-related macular degeneration.

The Journal of experimental medicine - 1 Oct 2007

Prosser Beverly E, Johnson Steven, Roversi Pietro, Herbert Andrew P, Blaum Bärbel S, Tyrrell Jess, Jowitt Thomas A, Clark Simon J, Tarelli Edward, Uhrín Dusan, Barlow Paul N, Sim Robert B, Day Anthony J, Lea Susan M

Abstract excerpt

Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His substitution at position 402, is linked to approximately 50% of attributable risks for AMD. We present the crystal structure of the region of FH containing the...

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Identifiers

PMID: 17893204
DOI: 10.1084/jem.20071069
PMCID: PMC2118454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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