Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translational mini-review series on complement factor H: structural and functional correlations for factor H.

Clinical and experimental immunology - 1 Jan 2008

Schmidt C Q, Herbert A P, Hocking H G, Uhrín D, Barlow P N

Abstract excerpt

The 155-kDa glycoprotein, complement factor H (CFH), is a regulator of complement activation that is abundant in human plasma. Three-dimensional structures of over half the 20 complement control protein (CCP) modules in CFH have been solved in the context of single-, double- and triple-module segments. Proven binding sites for C3b occupy the N and C termini of this elongated molecule and may be brought together...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement C3

Share to Complement Factor H

Share to Models, Molecular

Share to Protein Conformation

Share to Sequence Alignment

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 18081691
DOI: 10.1111/j.1365-2249.2007.03553.x
PMCID: PMC2276926

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translational mini-review series on complement factor H: structural and functional correlations for factor H.PMID 18081691Read ↗

Structural Analysis of the C-Terminal Region (Modules 18–20) of Complement Regulator Factor H (FH)Semantic proximity Read ↗

Functional Anatomy of Complement Factor HSemantic proximity Read ↗

The human complement factor H: functional roles, genetic variations and disease associations.Semantic proximity Read ↗

Factor H family proteins: on complement, microbes and human diseases.Semantic proximity Read ↗

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.Semantic proximity Read ↗

Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.Semantic proximity Read ↗

Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.Semantic proximity Read ↗

The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?Semantic proximity Read ↗

The human factor H protein family – an updateSemantic proximity Read ↗

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein FamilySemantic proximity Read ↗

Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.Semantic proximity Read ↗

Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.