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Article

Tandem duplication/triplication correlated with poly-cytosine stretch variation in human mitochondrial DNA D-loop region.

Mutagenesis - 1 Mar 2008

Hung Wen-Yi, Lin Jin-Ching, Lee Liang-Ming, Wu Chew-Wun, Tseng Ling-Ming, Yin Pen-Hui, Chi Chin-Wen, Lee Hsin-Chen

Abstract excerpt

Somatic mutations in the mitochondrial DNA (mtDNA) displacement loop (D-loop) region have been frequently detected in various human cancers. In a previous study, we identified a polyplasmic 260-bp tandem duplication and triplication mutation in the mtDNA D-loop of one gastric cancer. In the present study, we adopted a more sensitive back-to-back polymerase chain reaction method to screen for this 260-bp tandem...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18252697
DOI: 10.1093/mutage/gen002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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