Article
Mitochondrial DNA alterations in thyroid cancer.
Journal of surgical oncology - 1 Mar 2003
Tong Betty C, Ha Patrick K, Dhir Karan, Xing Mingzhao, Westra William H, Sidransky David, Califano Joseph A
Abstract excerpt
BACKGROUND: Alterations in mitochondrial DNA have been identified in a number of solid tumor types, including gastric, head and neck, breast, colorectal, lung, and bladder carcinomas. Recently, a homopolymeric C stretch (D310) located within the noncoding D-loop of the mitochondrial genome was identified and described as a mutational hotspot. The objective of the present study was to examine a series of thyroid...
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