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Article

Nucleotide sequence variation is frequent in the mitochondrial DNA displacement loop region of individual human tumor cells.

Molecular cancer research : MCR - 1 Jan 2005

Yoneyama Haruko, Hara Toshiko, Kato Yo, Yamori Takao, Matsuura Etsuko T, Koike Katsuro

Abstract excerpt

The mitochondrial DNA (mtDNA) displacement loop (D-loop) regions of 76 various tumor cell lines were examined to investigate the existence of a specific relationship between a somatic mtDNA sequence and initiation and/or progression of a tumor. Based on molecular cloning-sequencing analysis, a nucleotide sequence in the D-loop region in each cell line was found to be homoplasmic. Several site-specific nucleotide...

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PMID: 15671245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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