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Article

The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling.

Journal of molecular biology - 28 Mar 2008

Li Zongli, Strunk Jennifer Julia, Lamken Peter, Piehler Jacob, Walz Thomas

Abstract excerpt

Type I interferons (IFNs) have pleiotropic effects, including antiviral, antiproliferative, and immunomodulatory responses. All type I IFNs bind to a shared receptor consisting of the two transmembrane proteins ifnar1 and ifnar2. We used negative stain electron microscopy to calculate a three-dimensional reconstruction of the ternary complex formed by a triple mutant IFN alpha2 with the ectodomains of ifnar1 and...

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Share to Cytokine Signaling Pathways and Interactions
Share to Interferon Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Electron, Transmission

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Share to Receptor, Interferon alpha-beta

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Source

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Identifiers

PMID: 18252254
DOI: 10.1016/j.jmb.2007.12.005
PMCID: PMC2577817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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