Article
Structural integrity with functional plasticity: what type I IFN receptor polymorphisms reveal.
Journal of leukocyte biology - 1 Sept 2020
de Weerd Nicole A, Vivian Julian P, Lim San S, Huang Stephanie U-Shane, Hertzog Paul J
Abstract excerpt
The type I IFNs activate an array of signaling pathways, which are initiated after IFNs bind their cognate receptors, IFNα/β receptor (IFNAR)1 and IFNAR2. These signals contribute to many aspects of human health including defense against pathogens, cancer immunosurveillance, and regulation of inflammation. How these cytokines interact with their receptors influences the quality of these signals. As such, the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.