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Article

Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor

13 Oct 2021

Abstract excerpt

, a New World alphavirus that causes severe neurological disease in humans. Here we present near-atomic-resolution cryo-electron microscopy reconstructions of VEEV virus-like particles alone and in a complex with the ectodomains of LDLRAD3. Domain 1 of LDLRAD3 is a low-density lipoprotein receptor type-A module that binds to VEEV by wedging into a cleft created by two adjacent E2-E1 heterodimers in one trimeric...

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PMID: 34646020
DOI: 10.1038/s41586-021-03963-9

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