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Article

Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography.

Structure (London, England : 1993) - 15 Dec 1996

Radhakrishnan R, Walter L J, Hruza A, Reichert P, Trotta P P, Nagabhushan T L, Walter M R

Abstract excerpt

BACKGROUND: The human alpha-interferon (huIFN-alpha) family displays broad spectrum antiviral, antiproliferative and immunomodulatory activities on a variety of cell types. The diverse biological activities of the IFN-alpha's are conveyed to cells through specific interactions with cell-surface receptors. Despite considerable effort, no crystal structure of a member of this family has yet been reported, because...

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PMID: 8994971
DOI: 10.1016/s0969-2126(96)00152-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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