Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters.

Genes, chromosomes & cancer - 1 May 2002

Kondo Keiichi, Yao Masahiro, Yoshida Minoru, Kishida Takeshi, Shuin Taro, Miura Takeshi, Moriyama Masatoshi, Kobayashi Kazuki, Sakai Naoki, Kaneko Shigeki, Kawakami Satoshi, Baba Masaya, Nakaigawa Noboru, Nagashima Yoji, Nakatani Yukio, Hosaka Masahiko

Abstract excerpt

To delineate more precisely the somatic von Hippel-Lindau disease (VHL) gene alteration as well as to elucidate its etiologic role in renal tumorigenesis, we examined a total of 240 sporadic renal cell carcinomas (RCCs) for somatic VHL gene alterations by DNA-SSCP followed by sequencing, methylation-specific PCR assay, microsatellite LOH study, and Southern blot analysis. Intragenic mutation of the VHL gene was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Southern
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Kidney Neoplasms

Share to Ligases

Share to Loss of Heterozygosity

Share to Ubiquitin-Protein Ligases

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 11921283
DOI: 10.1002/gcc.10054

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters.PMID 11921283Read ↗

VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma.Semantic proximity Read ↗

Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinomaSemantic proximity Read ↗

Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review.Semantic proximity Read ↗

VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation.Semantic proximity Read ↗

Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors.Semantic proximity Read ↗

Analysis of <i>VHL</i> Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell CarcinomaSemantic proximity Read ↗

Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer.Semantic proximity Read ↗

Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors.Semantic proximity Read ↗

Mutational status of VHL gene and its clinical importance in renal clear cell carcinoma.Semantic proximity Read ↗

Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma.Semantic proximity Read ↗

Von Hippel-Lindau disease and sporadic renal cell carcinoma.Semantic proximity Read ↗

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.