Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors.

doi:10.1371/journal.pgen.1002312

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Article

Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors.

PLoS genetics - 1 Oct 2011

Moore Lee E, Nickerson Michael L, Brennan Paul, Toro Jorge R, Jaeger Erich, Rinsky Jessica, Han Summer S, Zaridze David, Matveev Vsevolod, Janout Vladimir, Kollarova Hellena, Bencko Vladimir, Navratilova Marie, Szeszenia-Dabrowska Neonilia, Mates Dana, Schmidt Laura S, Lenz Petra, Karami Sara, Linehan W Marston, Merino Maria, Chanock Stephen, Boffetta Paolo, Chow Wong-Ho, Waldman Frederic M, Rothman Nathaniel

Abstract excerpt

Renal tumor heterogeneity studies have utilized the von Hippel-Lindau VHL gene to classify disease into molecularly defined subtypes to examine associations with etiologic risk factors and prognosis. The aim of this study was to provide a comprehensive analysis of VHL inactivation in clear cell renal tumors (ccRCC) and to evaluate relationships between VHL inactivation subgroups with renal cancer risk factors and...

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PMID: 22022277
DOI: 10.1371/journal.pgen.1002312
PMCID: PMC3192834

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