Article
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 1994
Herman J G, Latif F, Weng Y, Lerman M I, Zbar B, Liu S, Samid D, Duan D S, Gnarra J R, Linehan W M
Abstract excerpt
Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that hypermethylation of a normally unmethylated CpG island in the 5' region provides another potentially important mech...
Topics
- Adenocarcinoma, Clear Cell
- Base Sequence
- Carcinoma, Renal Cell
- Chromosome Aberrations
- DNA Primers
- DNA, Neoplasm
- Dinucleoside Phosphates
- Exons
- Genes, Tumor Suppressor
- Humans
- Kidney Neoplasms
- Methylation
- Molecular Sequence Data
- Mutation