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Article

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 1994

Herman J G, Latif F, Weng Y, Lerman M I, Zbar B, Liu S, Samid D, Duan D S, Gnarra J R, Linehan W M

Abstract excerpt

Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that hypermethylation of a normally unmethylated CpG island in the 5' region provides another potentially important mechanism for inactivation of the VHL gene in a significant portion of these cancers. This hypermethylation was found in 5...

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Identifiers

PMID: 7937876
DOI: 10.1073/pnas.91.21.9700
PMCID: PMC44884

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.PMID 7937876Read ↗

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The Clinicopathological Significance of Epigenetic Silencing of VHL Promoter and Renal Cell Carcinoma: A Meta-AnalysisSemantic proximity Read ↗

Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors.Semantic proximity Read ↗

Genetic and epigenetic alterations in the von hippel-lindau gene: the influence on renal cancer prognosis.Semantic proximity Read ↗

Analysis of <i>VHL</i> Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell CarcinomaSemantic proximity Read ↗

The von Hippel-Lindau geneSemantic proximity Read ↗

Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis.Semantic proximity Read ↗

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Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors.Semantic proximity Read ↗

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