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Article

Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication.

Molecular and cellular biology - 1 Oct 1998

Kamimura Y, Masumoto H, Sugino A, Araki H

Abstract excerpt

The DPB11 gene, which genetically interacts with DNA polymerase II (epsilon), one of three replicative DNA polymerases, is required for DNA replication and the S phase checkpoint in Saccharomyces cerevisiae. To identify factors interacting with Dbp11, we have isolated sld (synthetically lethal wi...

Topics

Amino Acid Sequence
Binding Sites
Carrier Proteins
Cell Cycle Proteins
Cell Division
DNA Replication
DNA, Fungal
Fungal Proteins
G1 Phase
Molecular Sequence Data
Mutation
S Phase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 9742127
DOI: 10.1128/MCB.18.10.6102
PMCID: PMC109196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9742127-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication.PMID 9742127Read ↗

Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint.Semantic proximity Read ↗

DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability.Semantic proximity Read ↗

Dpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase.Semantic proximity Read ↗

Essential functions of the 32 kDa subunit of yeast replication protein A.Semantic proximity Read ↗

DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint.Semantic proximity Read ↗

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.Semantic proximity Read ↗

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.Semantic proximity Read ↗

NDD1, a high-dosage suppressor of cdc28-1N, is essential for expression of a subset of late-S-phase-specific genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.Semantic proximity Read ↗

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