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Article

DNA polymerase delta is required for base excision repair of DNA methylation damage in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 1994

Blank A, Kim B, Loeb L A

Abstract excerpt

We present evidence that DNA polymerase delta of Saccharomyces cerevisiae, an enzyme that is essential for viability and chromosomal replication, is also required for base excision repair of exogenous DNA methylation damage. The large catalytic subunit of DNA polymerase delta is encoded by the CDC2(POL3) gene. We find that the mutant allele cdc2-2 confers sensitivity to killing by methyl methanesulfonate (MMS)...

Topics

Alleles
Animals
DNA Polymerase I
DNA Polymerase III
DNA Repair
DNA-Directed DNA Polymerase
Genetic Complementation Test
In Vitro Techniques
Methyl Methanesulfonate
Methylation
Rats

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Saccharomyces cerevisiae

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Identifiers

PMID: 8090767
DOI: 10.1073/pnas.91.19.9047
PMCID: PMC44744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8090767-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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DNA polymerase delta is required for base excision repair of DNA methylation damage in Saccharomyces cerevisiae.PMID 8090767Read ↗

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