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Article

Sequence-dependent effect of interruptions on microsatellite mutation rate in mismatch repair-deficient human cells.

Mutation research - 2 Apr 2008

Boyer Jayne C, Hawk Joshua D, Stefanovic Lela, Farber Rosann A

Abstract excerpt

Although microsatellite mutation rates generally increase with increasing length of the repeat tract, interruptions in a microsatellite may stabilize it. We have performed a direct analysis of the effect of microsatellite interruptions on mutation rate and spectrum in cultured mammalian cells. Two mononucleotide sequences (G(17) and A(17)) and a dinucleotide [(CA)(17)] were compared with interrupted repeats of...

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Source

Identifiers

PMID: 18242644
DOI: 10.1016/j.mrfmmm.2007.12.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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