Article
DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences.
Nucleic acids research - 1 Feb 2008
Hile Suzanne E, Eckert Kristin A
Abstract excerpt
Microsatellites are ubiquitously present in eukaryotic genomes and are implicated as positive factors in evolution. At the nucleotide level, microsatellites undergo slippage events that alter allele length and base changes that interrupt the repetitive tract. We examined DNA polymerase errors within a [T](11) microsatellite using an in vitro assay that preferentially detects mutations other than unit changes. We...
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