Article
Mismatch repair blocks expansions of interrupted trinucleotide repeats in yeast.
Molecular cell - 1 Dec 2000
Rolfsmeier M L, Dixon M J, Lahue R S
Abstract excerpt
Disease-causing expansions of trinucleotide repeats (TNRs) can occur very frequently. In contrast, expansions are rare if the TNR is interrupted (imperfect). The molecular mechanism stabilizing interrupted alleles and thereby preventing disease has been elusive. We show that mismatch repair is the major stabilizing force for interrupted TNRs in Saccharomyces cerevisiae. Interrupted alleles expand much more often...
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