Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation rate and specificity analysis of tetranucleotide microsatellite DNA alleles in somatic human cells.

Molecular carcinogenesis - 1 Jul 2002

Eckert Kristin A, Yan Guang, Hile Suzanne E

Abstract excerpt

We have systematically varied microsatellite sequence composition to determine the effects of repeat unit size, G+C content, and DNA secondary structure on microsatellite stability in human cells. The microsatellites were inserted in frame within the 5' region of the herpes simplex virus thymidine kinase (HSV-tk) gene. The polypyrimidine/polypurine microsatellites displayed enhanced S1 nuclease sensitivity in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to DNA Mutational Analysis
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microsatellite Repeats

Share to Mutagenesis

Share to Simplexvirus

Share to Single-Strand Specific DNA and RNA Endonucleases

Share to Thymidine Kinase

Source

Identifiers

PMID: 12112308
DOI: 10.1002/mc.10058

Genes

TCTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation rate and specificity analysis of tetranucleotide microsatellite DNA alleles in somatic human cells.PMID 12112308Read ↗

Somatic mutation rates and specificities at TC/AG and GT/CA microsatellite sequences in nontumorigenic human lymphoblastoid cells.Semantic proximity Read ↗

Every microsatellite is different: Intrinsic DNA features dictate mutagenesis of common microsatellites present in the human genome.Semantic proximity Read ↗

Mutational dynamics of microsatellites.Semantic proximity Read ↗

Heterogeneous mutation processes in human microsatellite DNA sequences.Semantic proximity Read ↗

The in vitro fidelity of yeast DNA polymerase δ and polymerase ε holoenzymes during dinucleotide microsatellite DNA synthesis.Semantic proximity Read ↗

Microsatellite instability in human cancer.Semantic proximity Read ↗

Sequence dependent instability of mononucleotide microsatellites in cultured mismatch repair proficient and deficient mammalian cells.Semantic proximity Read ↗

What is a microsatellite: a computational and experimental definition based upon repeat mutational behavior at A/T and GT/AC repeats.Semantic proximity Read ↗

Mutation rate of a microsatellite sequence in normal human fibroblasts.Semantic proximity Read ↗

[Human microsatellites: mutation and evolution].Semantic proximity Read ↗

The mutational spectrum of human autosomal tetranucleotide microsatellites.Semantic proximity Read ↗

Human postmeiotic segregation 2 exhibits biased repair at tetranucleotide microsatellite sequences.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.