Article
Length of CTG.CAG repeats determines the influence of mismatch repair on genetic instability.
Journal of molecular biology - 16 Jun 2000
Parniewski P, Jaworski A, Wells R D, Bowater R P
Abstract excerpt
We showed previously that mutations in methyl-directed mismatch repair of Escherichia coli reduced the occurrence of large deletions in (CTG.CAG)(175) repeats contained on plasmids. By contrast, other workers reported that mutations in mismatch repair increase the frequency of small-length changes in the shorter (CTG.CAG)(64). Using plasmids with a variety of lengths and purity of (CTG.CAG) repeats, we have...
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