Mutation rate of a microsatellite sequence in normal human fibroblasts.

Article

Mutation rate of a microsatellite sequence in normal human fibroblasts.

Cancer research - 1 Sept 1998

Boyer J C, Farber R A

Abstract excerpt

Dinucleotide repeats, because of their repetitive nature, are prone to frameshift mutations, most likely via a DNA-polymerase slippage mechanism. Mutation rates in microsatellite DNA sequences are high in mismatch repair-defective cells. In normal cells, only estimates of maximal rates of mutatio...

Topics

Cells, Cultured
Dinucleotide Repeats
Fibroblasts
Humans
Microsatellite Repeats
Mutation

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