Article
Stabilizing effects of interruptions on trinucleotide repeat expansions in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Jan 2000
Rolfsmeier M L, Lahue R S
Abstract excerpt
In most trinucleotide repeat (TNR) diseases, the primary factor determining the likelihood of expansions is the length of the TNR. In some diseases, however, stable alleles contain one to three base pair substitutions that interrupt the TNR tract. The unexpected stability of these alleles compared to the frequent expansions of perfect TNRs suggested that interruptions somehow block expansions and that expansions...
Topics
- Alleles
- DNA, Fungal
- Mutation
- Saccharomyces cerevisiae
- Trinucleotide Repeats