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Article

Isthmus Stem Cells Are the Origins of Metaplasia in the Gastric Corpus

6 Mar 2017

Abstract excerpt

The acquisition of genetic/epigenetic mutations in long-lived gastrointestinal stem cells leads to the development of cancer, as well as precancerous lesions such as metaplasia and dysplasia. In the proximal stomach corpus, this model of progression from stem cells has been supported by studies in mice and human beings, showing abundant proliferation in the isthmus and clonal expansion of mutated cells from the...

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PMID: 28560293
DOI: 10.1016/j.jcmgh.2017.02.009

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