Article
Exacerbating role of gammadelta T cells in chronic colitis of T-cell receptor alpha mutant mice.
Gastroenterology - 1 Feb 2008
Nanno Masanobu, Kanari Yasuyoshi, Naito Tomoaki, Inoue Nagamu, Hisamatsu Tadakazu, Chinen Hiroshi, Sugimoto Ken, Shimomura Yasuyo, Yamagishi Hideo, Shiohara Tetsuo, Ueha Satoshi, Matsushima Kouji, Suematsu Makoto, Mizoguchi Atsushi, Hibi Toshifumi, Bhan Atul K, Ishikawa Hiromichi
Abstract excerpt
BACKGROUND & AIMS: T-cell receptor (TCR) gammadelta T cells are an important component of the mucosal immune system and regulate intestinal epithelial homeostasis. Interestingly, there is a significant increase in gammadelta T cells in the inflamed mucosa of patients with ulcerative colitis (UC). However, the role of gammadelta T cells in chronic colitis has not been fully identified. METHODS: TCRalpha-deficient...
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